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It affects an estimated 20 million Americans and can cause short-term issues such as snoring, brain fog and daytime sleepiness but also severe long-term issues such as heart disease, dementia and early death

However, acute gastrointestinal distress, dehydration, or poor oral intake during dose escalation can theoretically reduce vaccine tolerability and optimal immune engagement

In severe cases, a sulfa allergy can cause a condition known as Stevens-Johnson syndrome, which is a life-threatening reaction that affects the skin and mucous membranes

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Drugs 29 , 13651375 (2020)