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Frequently Asked Questions Is it safe to use GLP-1 for only a few months

The SURMOUNT-5 trial, published in 2025 in the New England Journal of Medicine, directly compared tirzepatide with semaglutide

But the messaging around GLP-1s and mental health has been a little confusing

Metformin is thought to exert these powerful effects primarily by counteracting insulin resistance to curtail hepatic glucose output and increase insulin-stimulated glucose uptake in muscle and fat [3]

Safety & Side Effects What are the most common side effects of Wegovy and Ozempic

An initial decline in eGFR is common after treatment initiation but typically stabilizes over time, contributing to long-term preservation of kidney function [108]