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There have been postmarketing reports of worsening renal function in patients taking sitagliptin with or without metformin, including acute renal failure, sometimes requiring dialysis

It is important to note that these side effects are typically dose-dependent, and starting on a lower dose may help mitigate discomfort

Clinical trials studying semaglutide in people with chronic kidney disease and type 2 diabetes showed a reduction in kidney disease progression and kidney-related death

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