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Cardiovascular effects Heart rate increased in a dose-dependent manner during the first 24 weeks of treatment, with the largest average increase being approximately 6.7 beats per minute at the 12 mg dose

doi: 10.1038/nrendo.2018.24 141 MoranLTeedeH

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In patients with type 2 diabetes mellitus (T2DM), supraphysiological doses of GLP1 normalize the endogenous insulin response during a hyperglycaemic clamp

The two most important incretin hormones responsible for this effect are glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide (GLP)-1

doi:10.1111/j.1463-1326.2008.01018.x 36