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Regarding renal effects, the evidence of SGLT2is in preventing kidney failure is more abundant than for GLP-1RAs, which showed a beneficial effect on albuminuria but not on hard kidney endpoints
This was prompted by the publication of a landmark article in the New England Journal of Medicine addressing the impact of this medication in a large clinical trial

New data from 333,000 patients: 3 years on: 18% risk of heart attack, stroke, death Stop at 12 months: +14% risk Stop at 18 months: benefit fully erased Stop at 24 months: +22% risk It takes 3 years to build it
As the use of GLP-1 receptor agonists continues to expand for the treatment of type 2 diabetes and obesity, questions have emerged about their potential gastrointestinal side effectsparticularly gastroesophageal reflux disease (GERD)

That means: If you have diabetes, getting your blood sugar and overall health optimized before pregnancy is crucial
