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Higher doses tend to produce more noticeable gastrointestinal symptoms during dose escalation, regardless of the medication

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GLP-1RAs and SGLT2 inhibitors also have pleiotropic effects, including blood glucose-dependent and -independent mechanisms, effects on the reninangiotensinaldosterone system and favourable effects on left ventricular and renal functions [35, 36]

This happens because the medications not only result in fat loss, but also muscle loss, Ortiz-Pujols explained

Employers and insurers know that widespread GLP-1 adoption at current prices could devastate their bottom lines unless there's clear evidence of financial ROI