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Clinicians may also advise timing medication relative to mealstaking injections at a consistent time and aligning meals to predictable patterns helps stabilize GI response

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In the Phase 2 retatrutide trial published in the New England Journal of Medicine (2023), participants at the highest dose (12 mg) achieved a mean body weight reduction of approximately 24.2% over 48 weeks

Further, the recent announcements will not impact costs for Medicaid enrollees as they already pay little or no copays for prescription drugs, and the costs of purchasing drugs directly from manufacturers through TrumpRx will likely still be prohibitive for people on Medicaid who must have a low income to qualify for the program

Roughly 30-40% of commercial plans cover Zepbound with prior authorization, requiring documented BMI 30 (or 27 with comorbidities) and ongoing diet and exercise programs

However, these medications do not directly target thyroid function or autoimmune processes, which is an important distinction when considering their potential role in Hashimoto's disease management