clinical trials glp 1 GLP1 agonists: current and future landscape of for patients with metabolic dysfunction Issue 42: GLP-1 RA Drug

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The FDA has approved GLP-1 receptor agonists such as Liraglutide, Semaglutide, and the GLP-1/GIP dual agonist Tirzepatide for the treatment of obesity [[16], [17], [18]]

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A subgroup of the PCOS-induced mice received liraglutide 0.2 mg/kg for 21 consecutive days (twice daily, s.c.), while the other subgroup was treated with saline injections twice daily

While tirzepatide is not primarily eliminated through the kidneys, the gastrointestinal effects of the medication, including potential nausea, vomiting, and diarrhea, could lead to dehydration and electrolyte imbalances that may be particularly problematic in patients with compromised kidney function

[DOI] [PMC free article] [PubMed] [Google Scholar] 51.Wu T, Rayner CK, Watson LE, Jones KL, Horowitz M, et al