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However, molecular understanding is limited by a lack of structural information on how different GLP-1R agonists engage with the GLP-1R

report here on a GIPR antagonist conjugated to GLP-1 analogues that reduces body weight and improves metabolic markers in preclinical and phase 1 clinical settings.

Using a DNA-based bioreceptor, the sensor continuously measures phenylalanine a key marker of muscle breakdown and protein intake

These medications enable cause-specific management of obesity complications.

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