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The Glucagon-like Peptide 1 (GLP-1) Receptor Agonist Exendin-4 Reduces Cocaine Self-Administration in Mice

Satterstrom FK, Kosmicki JA, Wang J, Breen MS, De Rubeis S, An JY, Peng M, Collins R, Grove J, Klei L, Stevens C, Reichert J, Mulhern MS, Artomov M, Gerges S, Sheppard B, Xu X, Bhaduri A, Norman U, Brand H, Schwartz G, Nguyen R, Guerrero EE, Dias C, Aleksic B, Anney R, Barbosa M, Bishop S, Brusco A, Bybjerg-Grauholm J, Carracedo A, Chan MCY, Chiocchetti AG, Chung BHY, Coon H, Cuccaro ML, Curr A, Dalla Bernardina B, Doan R, Domenici E, Dong S, Fallerini C, Fernndez-Prieto M, Ferrero GB, Freitag CM, Fromer M, Gargus JJ, Geschwind D, Giorgio E, Gonzlez-Peas J, Guter S, Halpern D, Hansen-Kiss E, He X, Herman GE, Hertz-Picciotto I, Hougaard DM, Hultman CM, Ionita-Laza I, Jacob S, Jamison J, Jugessur A, Kaartinen M, Knudsen GP, Kolevzon A, Kushima I, Lee SL, Lehtimki T, Lim ET, Lintas C, Lipkin WI, Lopergolo D, Lopes F, Ludena Y, Maciel P, Magnus P, Mahjani B, Maltman N, Manoach DS, Meiri G, Menashe I, Miller J, Minshew N, Montenegro EMS, Moreira D, Morrow EM, Mors O, Mortensen PB, Mosconi M, Muglia P, Neale BM, Nordentoft M, Ozaki N, Palotie A, Parellada M, Passos-Bueno MR, Pericak-Vance M, Persico AM, Pessah I, Puura K, Reichenberg A, Renieri A, Riberi E, Robinson EB, Samocha KE, Sandin S, Santangelo SL, Schellenberg G, Scherer SW, Schlitt S, Schmidt R, Schmitt L, Silva IMW, Singh T, Siper PM, Smith M, Soares G, Stoltenberg C, Suren P, Susser E, Sweeney J, Szatmari P, Tang L, Tassone F, Teufel K, Trabetti E, Trelles M, Walsh CA, Weiss LA, Werge T, Werling DM, Wigdor EM, Wilkinson E, Willsey AJ, Yu TW, Yu MHC, Yuen R, Zachi E, Agerbo E, Als TD, Appadurai V, Bkvad-Hansen M, Belliveau R, Buil A, Carey CE, Cerrato F, Chambert K, Churchhouse C, Dalsgaard S, Demontis D, Dumont A, Goldstein J, Hansen CS, Hauberg ME, Hollegaard MV, Howrigan DP, Huang H, Maller J, Martin AR, Martin J, Mattheisen M, Moran J, Pallesen J, Palmer DS, Pedersen CB, Pedersen MG, Poterba T, Poulsen JB, Ripke S, Schork AJ, Thompson WK, Turley P, Walters RK, Betancur C, Cook EH, Gallagher L, Gill M, Sutcliffe JS, Thurm A, Zwick ME, Brglum AD, State MW, Cicek AE, Talkowski ME, Cutler DJ, Devlin B, Sanders SJ, Roeder K, Daly MJ, Buxbaum JD (2020) Large-scale exome sequencing study implicates both developmental and functional changes in the neurobiology of autism

This powerful combination represents a new frontier in weight management research, bringing together an amylin receptor agonist with a triple-receptor agonist to create a multi-mechanism approach that addresses metabolic function through complementary pathways