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In January of this year, the FDA noted that it had "received adverse event reports after patients used compounded semaglutide" and that "patients should not use a compounded drug if an approved drug is available to treat a patient." In July, the agency followed up with a notice that it had "received reports of adverse events, some requiring hospitalization, that may be related to overdoses due to dosing errors associated with compounded semaglutide injectable products." And in August, Eli Lilly, the maker of Zepbound and Mounjaro, sent a series of cease-and-desist letters to providers urging them to stop prescribing compounded versions of those drugs

The shortage list removal Tirzepatide was removed from the FDA drug shortage list on October 2, 2024

The landscape for guidelines and recommendations is also changing, with a higher emphasis on efficacy than before

The MC4R rs17782313 variant, linked to appetite regulation, and the FTO rs9939609 variant, affecting metabolic efficiency, also influence how your body processes GLP-1 signals

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