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Description
RNF6 inhibits GDF9-induced follicle arrest by ubiquitination of AR

Although no current evidence suggests that GLP-1RAs induce -catenin mutations or APC deficiencies, it is hypothesized that prolonged use of GLP-1RAs may foster the proliferative progression of colorectal cancer cells and pancreatic -cells, based on their mechanisms of action [99]
Only when Eli Lilly began testing dual GLP-1/GIP agonists did the picture change dramatically

This can lead to serious injury, coma, or death

Sci Rep 10: 2823, 2020

Risk of orthostatic hypotension associated with sodium-glucose cotransporter-2 inhibitor treatment: a meta-analysis of randomized controlled trials