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Regulatory Information Disclaimer: Statements in this article regarding FDA actions, the 503B Bulks List, drug shortage status, and the federal regulatory framework for compounded GLP-1 medications reflect FDA published guidance current as of May 2026

Heroin withdrawal model, Exendin-4 intervention, and behavioral testing Forty-eight male C57BL/6J mice were randomly divided into a heroin-dependent group (n = 24) and a saline control group (n = 24)

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For people with T2D, a phase 2 trial showed that 12 weeks of efinopegdutide achieve up to 7.9% WL (compared to 0.7% WL with placebo) without actual improvement in HbA1c [78]

The SURMOUNT trials showed continued improvement in depression scores through week 72