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Reported weight change in older adults and presence of frailty

119 demonstrated that exenatide combined with metformin ( n = 19 patients) led to more pronounced reductions in body weight (mean reduction of 4.5 kg) and WC (by 4 cm) compared to metformin alone ( n = 21 patients)

In the SMART trial, Semaglutide 2.4 mg reduced albuminuria in people with overweight or obesity and CKD without diabetes with 52% reduction in UACR

The effect of metformin on blood pressure, plasma cholesterol and triglycerides in type 2 diabetes mellitus: a systematic review

In many cases, adjustments to dosing or additional support can make treatment tolerable