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Healthcare providers will ask about these side effects during follow-up visits and may adjust the dose or suggest stopping the medicine if symptoms are too strong

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For example, if GLP-1 activation reduces appetite but also triggers compensatory reductions in metabolic rate, adding glucagon receptor activation that increases energy expenditure counteracts this adaptation

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At the same time, people who regularly enjoy a healthy amount of sleep around 79 hours per night tend to lose more weight and body fat

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