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We conducted high resolution meal pattern analysis using home cage FED pellet dispensers (Feeding Experimentation Device 28 ), and observational analysis of liquid diet intake, to test the effects of chemogenetic inhibition of PPG NTS neurons on termination of large solid and liquid meals, using the inhibitory hM4Di Designer Receptor Exclusively Activated by Designer Drugs (DREADD

Steel cut oats chop whole oat grains into pin head sized pieces

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These results confirm previous work demonstrating that cells can produce active GLP-1 (30, 67) and, further, that active GLP-1 production is amplified in response to a GLP-1R agonist

Additionally, blockade of GLP-1Rs in the LS with exendin-9 alone enhanced sucrose and oil intake indicating a physiologic role for these neurons to suppress food intake

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