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Tissue-specific effects of leptin on glucose and lipid metabolism

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Bullmore E, Sporns O

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Patients should be advised to: Start with the lowest dose and increase slowly Eat smaller, more frequent meals Avoid high-fat foods Stay well-hydrated Safety monitoring should include vigilance for: Pancreatitis symptoms (severe persistent abdominal pain) discontinue immediately if suspected Gallbladder disease increased risk with rapid weight loss Hypoglycaemia particularly when combined with insulin or sulphonylureas Renal function deterioration especially with dehydration from gastrointestinal effects Diabetic retinopathy monitor in patients with pre-existing retinopathy, particularly with semaglutide Suspected adverse reactions should be reported via the MHRA Yellow Card scheme

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And finally, this is not the last GLP-1 drug

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Ozempic: semaglutide (Novo Nordisk) Type 2 diabetes

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If appetite is severely suppressed, prioritize protein and micronutrients in the meals you do eat, quality over quantity

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