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In an insulin-resistant milieu, insulin may competitively inhibit IDE, which impedes the degradation of A proteins, increases their neurotoxicity, and contributes to the onset of AD (Scherer et al., 2021
Ganly I, Ibrahimpasic T, Rivera M, Nixon I, Palmer F, Patel SG, Tuttle RM, Shah JP, Ghossein R
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Long-term use should be carefully monitored by a healthcare provider, as the medication may have potential side effects