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GLP-1 is an endogenous incretin hormone produced by intestinal enteroendocrine L-cells following nutrient ingestion [6]

low blood sugar (hypoglycemia)

This inhibitory effect is attributed to the activation of the adenosine monophosphate (AMP)-activated protein kinase (AMPK) signaling pathway and the concurrent downregulation of forkhead Box A1 (FOXA1) and sonic hedgehog (SHH) expression (Xie et al., 2020)

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One study assessed changes in anticipatory food reward responses in adults with Prader-Willi Syndrome versus healthy controls, but they found no correlation between these changes and levels of fasting ghrelin (van Nieuwpoort et al., 2021)

[DOI] [PubMed] [Google Scholar] 5.Nauck MA, Heimesaat MM, Orskov C, Holst JJ, Ebert R, Creutzfeldt W