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Among adults with overweight or obesity without diabetes, once-weekly subcutaneous semaglutide compared with once daily subcutaneous liraglutide, added to counseling for diet and physical activity, resulted in significantly greater weight loss at 68 weeks

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The medication may cause more nausea during early treatment due to direct contact with the stomach compared to injectable medications such as Ozempic and Wegovy

However, the potential for delaying or preventing the progression of T2DM in patients treated with GIP and GLP-1 remains uncertain, as there is currently no definitive evidence from human studies demonstrating that enhanced incretin activity directly affects -cell mass or alters the progressive loss of insulin secretory capacity in humans