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We assessed the efficacy and safety of semaglutide versus the dipeptidyl peptidase-4 (DPP-4) inhibitor sitagliptin in patients with type 2 diabetes inadequately controlled on metformin, thiazolidinediones, or both

2021;27:e933084

By contrast, the secondary outcome was the effect of the medications on body weight loss (change in body weight from baseline) during the treatment period

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Ozempic is the brand name for semaglutide, a drug developed to treat Type 2 diabetes in humans

These findings link previously reported robust clinical outcomes with underlying biochemical mechanisms, although the post-hoc exploratory analysis remains hypothesis-generating and does not prove causality