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We highlight 3 decades of science from multiple laboratories supporting the development of GLP-1 and GLP-2based therapies
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Conversely, constipation may lead to hard stools, straining, and hemorrhoidal engorgement

The STEP trials demonstrated that semaglutide 2.4 mg injected weekly produces 15% to 18% body weight reduction over 68 weeks, significantly exceeding placebo and lifestyle modification alone
