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Wegovy produces roughly twice the weight loss of Contrave in clinical trials, with participants losing an average of 35 lbs over 68 weeks versus 12-15 lbs with Contrave over a similar period

In June 2025, MBX Biosciences announced that it has submitted an IND application to the FDA for MBX 4291, a long-acting GLP-1/GIP receptor co-agonist prodrug targeting obesity, which received regulatory clearance in July

Many of these side effects are a direct result of its mechanism of action, and patients are not advised to initiate on a high dose of Ozempic

The cost difference you'd expect at most providers doesn't apply here

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