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Key milestones highlighted in this timeline: 1999 Orlistat (Xenical) The first long-term FDA-approved anti-obesity medication of the modern era

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Semaglutide works by signaling fullness to the brain, helping manage the appetite surge and insulin resistance that accompany hormonal transition

The article explores how medications like semaglutide and tirzepatide, originally approved for diabetes and obesity, are increasingly being prescribed off-label to address underlying metabolic issues such as insulin resistance, weight gain, and hormonal []

This once-weekly treatment supports metabolic balance as part of a structured 3-month care plan

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