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A study has shown that anticipation of food in the pre-ingestive stage, without ingestion and triggered solely by sensory detection of food, led to a rapid increase in calcium activity of PVH GLP-1R neurons

The study focused on first-generation GLP-1 drugs like liraglutide

All evaluated GLP-1 RAs led to a significant increase in nausea risk, with orforglipron showing the highest risk, followed by exenatide, tirzepatide, semaglutide, and liraglutide

The new trial thus strongly reinforces the benefit of GLP-1 for heart failure with preserved ejection fraction and extends that to people with Type 2 diabetes

Genetic cause of hyperglycaemia and response to treatment in diabetes

Both drugs work on appetite and metabolism through different pathways, and stacking them can create unpredictable side effects and health risks that outweigh potential benefits