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Side Effect Profile Both medications have similar side effect profiles, with gastrointestinal issues being the most common: Nausea Diarrhea Vomiting Constipation Abdominal pain While the incidence of side effects is generally similar between the two medications, some studies suggest that tirzepatide may have a slightly higher rate of gastrointestinal side effects, particularly at higher doses

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We found that exendin-phe1 favored G protein signaling, whilst exendin-asp3 favored -arrestin recruitment