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[DOI] [PMC free article] [PubMed] [Google Scholar] 58.Gu Y., Sun L., He Y., Yang L., Deng C., Zhou R., Kong T., Zhang W., Chen Y., Li J., et al

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However, the agencies analyses at the time were hindered by the small number of reported instances of suicidal thoughts and behaviors, resulting in what the FDA on Monday called considerable uncertainty in the risk estimate. For more clarity on the matter, the agency conducted a meta-analysis of different GLP-1 trials, encompassing more than 90 studies and nearly 108,000 patients

However, if extremely high doses are given for a long time, pyridoxine can cause nerve damage leading to numbness or tingling in the hands and feet (peripheral neuropathy)

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