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In circulation, the larger size of the complexes could protect the bound peptide from renal clearance and reduce the rate of distribution to extravascular compartments

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Although the renoprotective effects of SGLT-2 inhibitors are maintained at these eGFRs, the glucose-lowering effects of SGLT-2 inhibitors are significantly impaired at low eGFRs

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Participants remained in-house for a minimum of 72 h after dosing (Fig

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