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With respect to body weight, cotadutide at 200 g led to weight loss of 3.22 kg on average versus 3.33 kg with liraglutide, but the 300 g dose led to weight loss of 5.02 kg albeit with far higher gastrointestinal adverse event rates than liraglutide (85)

Dilley, A., Adhikari, S., Silwal, P., L

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SA-treated animals also had increased colonic EKR1/2 and prohormone convertase 1/3 proteins (PC1/3) protein phosphorylation

Of those, an estimated 10 million-plus have obesity that could qualify under the new rules