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The ongoing dedicated ophthalmic trial named as FOCUS study, which aims to evaluate semaglutides long-term effects on diabetic retinopathy, is now ongoing and could contribute to a comprehensive understanding of the true risk-benefit profile of these agents in patients with or at risk for diabetic retinopathy (NCT03811561) [104]

Furthermore, severe allergic reactions to tirzepatide should not be overlooked (Tirzepatide Side Effects n.d.)

12 weeks (1x daily, 5-on/2-off) 4 vials 60 doses needed (5x12)

doi: 10.3389/fendo.2020.559446 164 GebrieDGetnetDManyazewalT

The four-pathway approach activates mechanisms that single or dual agonists cannot reach, potentially overcoming resistance that develops with prolonged use of less comprehensive compounds

9 Should You Wait for Oral Options