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Longitudinal analysis by Ong et al

Before a drug can legally be marketed for a new intended use or indication for use (e.g., new patient population), the safety and efficacy of the new intended use or indication for use must be demonstrated through well-controlled clinical trials

Diabetes Care 48 (7), 10571082

Moving to a new spot each time keeps tissue healthy and ensures consistent absorption

it involves complex biological factors like hormones and metabolism

Both GLP-1RA and SGLT-2 inhibitors were associated with a lower risk (10% and 31%, respectively) as compared with placebo, and an even greater lower risk as compared with DPP-4 inhibitors (15% and 35%, respectively)