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population and significantly reduces how efficiently the body burns calories

The incretin glucagon-like peptide-1 (GLP-1), released from the gut during food intake, amplifies glucose-stimulated insulin release by binding to and activating its cognate G protein-coupled receptor (GPCR), the GLP-1 receptor (GLP-1R), triggering cAMP generation and downstream Protein Kinase A (PKA) and Exchange Protein Activated by cyclic AMP 2 (Epac2) signalling 4 , a process that has been exploited to develop pharmacological GLP-1R agonists (GLP-1RAs) as T2D therapies

It is well-known as a glucagon-like peptide-1 receptor agonist ( GLP-1 RA ), which mimics the GLP-1 hormone the human body produces after a meal, causing the pancreas to release more insulin