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11 Resistance or strength training is particularly emphasized for muscle preservation

The present findings on GLP-1RA use in T2DM patients are concordant with results of prior meta-analyses from our group 13 and others (summarized in Supplemental Table S1), 14 20 as well as data from real-world observational and pharmacovigilance studies, 43,44 that have established the robust cardiovascular and cerebrovascular benefits from GLP-1RAs in T2DM and laid the ground for their broader incorporation in clinical practice guidelines

As well, exendin-4 (50 nM) and cyclic adenosine monophosphate (cAMP) response element-binding protein overexpression additively protected transplanted human islets in streptozotocin- (STZ-) induced diabetic nude mice [44]

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These damage the mucosal tissue and reduce absorption