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Interesting data regarding the potential anti-cancer activity of pioglitazone come from studies performed with a transgenic mouse model characterized by a PAX8-PPAR fusion protein (PPFP) (found in 30% of follicular thyroid carcinomas)

The results of the major studies and other informationof SURPASS Program are summarized in Table 1

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Furthermore, metabolic syndrome (MetS) in PsD is linked to systemic inflammation, with obesity, insulin resistance, and adipokines further aggravating metabolic imbalances [14]