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In the Retatrutide Phase 2 obesity trial, the weight-loss curve had not clearly flattened by week 48

Those numbers help set expectations, but theyre averages, not guarantees

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This increases the risk of hormone imbalance, mood disorders, liver damage, and other related side effects

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Now a growing number of researchers, payers and providers are exploring deliberate "deprescription," which aims to taper some patients off their medication after they have taken it for a certain amount of time or lost a certain amount of weight