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First-time users were defined as individuals who did not have GLP-1 RAs listed on their health records for at least 365 days and who only initiated the medications as a second-line treatment to metformin

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That counseling is as important as the prescription itself

But the moment travel enters the equation, every single one of those controlled conditions disappears

Vital signs Blood pressure and heart rate were stable during the trial, mean arterial pressure was lower at 12 weeks in the exenatide group compared to placebo, 6.7 mmHg (3.6), P = 0.088, but there was no significant change within arms between baseline and 12 weeks (Supplementary Table 4)

(2023, Nature), four weeks of oral dosing in mice increased treadmill running distance by ~70 %, expanded type-IIa oxidative fibers, and elevated mitochondrial content even in sedentary animals [1]