glp-1 discontinuation weight regain loss maintenance after discontinuing : r/Zepbound A Comprehensive Review on Weight

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For patients with type 2 diabetes or metabolic syndrome, these metabolic benefits may justify continued treatment even after weight loss goals are met

Notably, usage of these drugs has escalated dramatically, with prescriptions increasing fortyfold since 2018, culminating in over 15 million Americans using these drugs as of the last month

This cytokine secretion leads to the activation of CNS-resident immune cells (such as microglia, astrocytes, and macrophages), as well as to the production of cytokines, increased antigen-presenting cell (APC) function, and the enhanced production of reactive oxygen species (ROS) and reactive nitrogen species [196]

Optometrists should advise their patients that although these medications are conclusively linked to an increased risk of NAION, the overall risk is still extremely low: only about 2.30 per 100,000 people are diagnosed with NAION each year