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This relationship mirrors the synergy between surgery and systemic therapy in oncology, where one modality targets macro-level disease (anatomical and hormonal reset) while the other addresses micro-level adaptations (homeostatic resistance)

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Further research is needed to assess effectiveness in a clinical setting

39 However, another study showed GLP-1 receptor agonists effect on the -cell mass in animal models where GLP-1 acted as a -cell growth factor leading to increased insulin synthesis and -cell mass 40

It is suspected that these benefits apply to other patient populations, although there are insufficient data to support such speculations, particularly in obese patients with AID