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GLP-1s offer significant promise to millions of Americans living with obesity, diabetes and/or cardiovascular disease, but their unprecedented demand and high price tags are creating challenging downstream impacts, including fluctuating supply, inconsistent clinical support, and runaway cost trajectory, said an Evernorth statement

A 2025 paper suggested the drugs may drive depression and suicidal ideation specifically in people with a genetic predisposition toward low dopamine function

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Diarrhea, constipation, vomiting, abdominal pain, and decreased appetite round out the typical complaints