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The SELECT trial, which supports the expanded indication, enrolled patients 45 years of age and older with pre-existing cardiovascular disease and a body-mass index of 27 or greater without diabetes

Glp-1: molecular mechanisms and outcomes of a complex signaling system

It contains semaglutide, a glucagon-like peptide-1 (GLP-1) receptor agonist, and is administered via a once-weekly subcutaneous injection

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Bu LL, Liu YQ, Shen Y, et al

The addition of an SGLT-2 inhibitor to existing GLP-1 receptor agonist use was also associated with a reduced risk of cardiovascular mortality and heart failure compared with GLP-1 receptor agonists alone