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doi: 10.1111/obr.13543

VESPER-1: the durability signal In a 32-week exploratory extension (Part B) of VESPER-1, Pfizer reports a 15.9% non-placebo-adjusted weight loss with no plateau observed at 32 weeks on 2.4 mg weekly berobenatide in participants who escalated from placebo to active drug

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GLP-1 receptors (GLP1R), which are found in pancreatic beta cells as well as other cell types, receive the GLP-1 signal, triggering the release of insulin

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Step five: the escalation schedule Once you have established your starting dose, follow a 4-week escalation pattern