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Kunos, G

infusion of liraglutide inhibits eating in rats by directly activating hypothalamic Pomc/Cart neurons in the ARC, without activating GLP-1-producing neurons in the hindbrain, and independent of GLP-1R signaling in vagal afferents, the area postrema (AP) and the PVN [686]

Unlike its predecessors, which often targeted a single pathway, tirzepatide interacts with both GLP-1 and GIP receptors

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It builds on the previously published consensus statement and aims to equip health professionals with evidence-based guidance to confidently integrate diabetes-specific nutrition formulas (DSNFs) into the management of diabetes in clinical practice