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GLP-1 receptor agonists are FDA-approved for multiple indications, primarily for type 2 diabetes management and weight loss, with semaglutide and liraglutide...

An underrated element of these diseases is that glucose uptake and energy utilization is much reduced in neurons

The GLP-1-induced enhancement of evoked EPSCs was abolished by a selective GLP-1 receptor antagonist, exendin 939, as well as by the extracellular application of a specific protein kinase A (PKA) inhibitor, KT5720

CFU = Colony Forming Units

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