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doi: 10.2337/dc09-1203

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[9] Following oral administration, melatonin undergoes first-pass hepatic metabolism primarily through cytochrome P450 enzymes, particularly CYP1A2, resulting in the formation of 6-sulfatoxymelatonin, which is subsequently eliminated through renal excretion

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[4] Unlike fenfluramine, phentermine does not directly activate serotonin receptors in cardiac valves