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GLP-1 RAs have been shown to result in increased residual gastric contents (RGCs) in patients undergoing EGDs and poor Boston Bowel Preparation Scores (BBPSs) in those undergoing colonoscopies

At the same time, payer policies often require discontinuation of GLP-1 therapy when a patients BMI drops below a set threshold, inadvertently triggering a frustrating cycle of weight loss and regainthe so-called yo-yo effect. This not only impacts ongoing adherence and persistence but also undermines the long-term cost-effectiveness of these therapies for healthcare systems

Investing in the Future of Metabolic Health For healthcare professionals, retatrutide represents a promising new addition to the arsenal against obesity and metabolic disease, potentially offering better patient outcomes with fewer side effects

Semaglutide side effects typically emerge within the first two weeks of starting treatment, peak around week three to four, and often improve as your body adapts

Both dietary approaches, when integrated with semaglutide therapy, have the potential to preserve lean body mass, reduce gastrointestinal adverse events, and enhance adherence through improved satiety and tolerability