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For instance, International Diabetes Federation in 2024 provided data according to which by 2050, projections show that 1 in 8 adults, approximately 853 million, will be living with diabetes, an increase of 46% and over 90% of people with diabetes have type 2 diabetes

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In receptor-binding studies, tirzepatide demonstrated a high affinity for the GIPR, comparable to that of native GIP, while its affinity for the GLP-1R is approximately 18- to 20-fold weaker than that of native GLP-1 [33]

Semaglutide works by targeting the GLP-1 receptors in the pancreas, brain and stomach

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