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Studies in the pig showed GLP-1 inhibited pancreatic secretion induced by hypoglycemia (central neural stimulation) but not that due to vagal nerve stimulation (126)

This gap exposes both safety hazards and deeper shortcomings in the overall patient experience
Semaglutide acid reflux versus pre-existing GERD: critical differences If you had GERD before starting semaglutide, your management approach needs adjustment

You start treatment and continue your life without interruption

When gastric emptying is slowed by GLP-1 medications, this gastric distension lasts longer , leading to pressure, bloating, and prolonged fullness
