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For balance between cohorts (semaglutide users and non-users), 1:2 nearest-neighbor propensity score matching was applied to account for demographic factors, contraindications for semaglutide, indications for semaglutide use, and use of NAION-associated drugs

Tirzepatide administration improves cognitive impairment in HFD mice by regulating the SIRT3-NLRP3 axis

[DOI] [PMC free article] [PubMed] [Google Scholar] 7.Ophthalmic complications associated with the antidiabetic drugs semaglutide and tirzepatide

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This mechanism produces rapid appetite reduction but carries risk of elevated heart rate, blood pressure, and potential dependency with prolonged use

Pressly, J