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Regarding co-agonist treatment, tirzepatide was recently shown in a post hoc analysis of the SURMOUNT-1 trial to also reduce UACR in overweight/obese people without T2D (88), and similar benefits for kidney function were shown in subjects with heart failure (89)

MariTide MariTide (maridebart cafraglutide, formerly AMG 133) is a GLP-1 receptor agonist conjugated to a human monoclonal antibody GIP receptor antagonist, administered subcutaneously once every four weeks (69)

Thats why its important to work with your care team to find the right dosage for you, rather than skipping doses or adjusting dosage on your own, he says

Pairing GLP-1 medications with strength training and high-protein diets may help reduce this risk, but its not always enough

Your care should be, too

55 A systematic review and meta-analysis of 7 RCTs was done to see the efficacy and safety of orforglipron and danuglipron in the treatment of T2DM and obesity