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Semaglutide at 2.4mg weekly (Wegovy) produces average weight loss of 15-17% in clinical trials, with many patients losing more than 20% of body weight

The FDA has also clarified that products applied to the skin rather than ingested do not meet the regulatory definition of dietary supplements

The risk-benefit balance may be less favourable for people near a normal BMI than for those who are clearly obese

Gala GLP-1 states this directly on its homepage: compounded GLP-1s "are not FDA-approved and are sourced from licensed compounding pharmacies." Compounded medications use active pharmaceutical ingredients sourced from FDA-registered facilities, but the finished compounded product itself is not reviewed or approved by the FDA

Proc Natl Acad Sci U S A 107(5):20482053

35,39 Further supporting the involvement of the autonomic nervous system in the positive chronotropic effect of GLP-1 in rodents is the lack of heart rate increases in response to GLP-1 in isolated perfused rat and mouse hearts